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Article

Blood as a surrogate marker for tissue‐specific DNA methylation and changes due to folate depletion in post‐partum female mice

24 Mar 2011

Abstract excerpt

SCOPE: DNA methylation patterns are tissue specific and may influence tissue-specific gene regulation. Human studies investigating DNA methylation in relation to environmental factors primarily use blood-derived DNA as a surrogate for DNA from target tissues. It is therefore important to know if DNA methylation changes in blood in response to environmental changes reflect those in target tissues. Folate intake...

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PMID: 21520493
DOI: 10.1002/mnfr.201100008

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