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Article

Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid

3 Feb 2014

Abstract excerpt

BACKGROUND: Epigenetic modifications, such as cytosine methylation in CpG-rich regions, regulate multiple functions in mammalian development. Maternal nutrients affecting one-carbon metabolism during gestation can exert long-term effects on the health of the progeny. Using C57BL/6 J mice, we investigated whether the amount of ingested maternal folic acid (FA) during gestation impacted DNA methylation in the...

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PMID: 24484737
DOI: 10.1186/1756-8935-7-3

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