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Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome

5 May 2015

Abstract excerpt

BACKGROUND: The manipulation of pregnancy diets in animals can lead to changes in DNA methylation with phenotypic consequences in the offspring. Human studies have concentrated on the effects of nutrition during early gestation. Lacking in humans is an epigenome-wide association study of DNA methylation in relation to perturbations in nutrition across all gestation periods. METHODS: We used the quasi-experimental...

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PMID: 25944819
DOI: 10.1093/ije/dyv043

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