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Protective and sex‐specific effects of moderate dose folic acid supplementation on the placenta following assisted reproduction in mice

14 Dec 2022

Abstract excerpt

Epigenetic defects induced by assisted reproductive technologies (ART) have been suggested as a potential mechanism contributing to suboptimal placentation. Here, we hypothesize that ART perturbs DNA methylation (DNAme) and gene expression during early placenta development, leading to abnormal placental phenotypes observed at term. Since folic acid (FA) plays a crucial role in epigenetic regulation, we propose...

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PMID: 36515682
DOI: 10.1096/fj.202201428r

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