Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse model

5 Mar 2019

Abstract excerpt

STUDY QUESTION: Could clinically-relevant moderate and/or high dose maternal folic acid supplementation prevent aberrant developmental and epigenetic outcomes associated with assisted reproductive technologies (ART)? SUMMARY ANSWER: Our results demonstrate dose-dependent and sex-specific effects of folic acid supplementation in ART and provide evidence that moderate dose supplements may be optimal for both sexes....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Assisted Reproductive Technology and Twin Pregnancy
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30989206
DOI: 10.1093/humrep/dez036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse modelPMID 30989206Read ↗

Protective and sex‐specific effects of moderate dose folic acid supplementation on the placenta following assisted reproduction in miceSemantic proximity Read ↗

Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylationSemantic proximity Read ↗

Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.Semantic proximity Read ↗

DNA Methylation Profiling at Single-Base Resolution Reveals Gestational Folic Acid Supplementation Influences the Epigenome of Mouse Offspring CerebellumSemantic proximity Read ↗

Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acidSemantic proximity Read ↗

Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in miceSemantic proximity Read ↗

High maternal folic acid intake around conception alters mouse blastocyst lineage allocation and expression of key developmental regulatory genesSemantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in miceSemantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in miceSemantic proximity Read ↗

Investigating the epigenetic mechanism behind transgenerational inheritance in mice with abnormal folate metabolismSemantic proximity Read ↗

Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomesSemantic proximity Read ↗

Risk of Excess Maternal Folic Acid Supplementation in OffspringSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.