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Article

Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.

Circulation - 10 May 2011

Jin Richard C, Mahoney Christopher E, Coleman Anderson Laura, Ottaviano Filomena, Croce Kevin, Leopold Jane A, Zhang Ying-Yi, Tang Shiow-Shih, Handy Diane E, Loscalzo Joseph

Abstract excerpt

BACKGROUND: Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke risk. METHODS AND RESULTS: We recently developed a genetic mouse model to assess platelet...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21518981
DOI: 10.1161/CIRCULATIONAHA.110.000034
PMCID: PMC3107543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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