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Article

Tumour suppressor function of protein tyrosine phosphatase receptor-T.

Bioscience reports - 1 Oct 2011

Scott Anthony, Wang Zhenghe

Abstract excerpt

It has long been thought that PTPs (protein tyrosine phosphatases) normally function as tumour suppressors. Recent high-throughput mutational analysis identified loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PTPRT (protein tyrosine phosphatase receptor-T), a member of the family of type IIB receptor-like...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Cytokine Signaling Pathways and Interactions
Share to Galectins and Cancer Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Protein Tyrosine Phosphatases

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21517784
DOI: 10.1042/BSR20100134
PMCID: PMC3116232

Genes

PTPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Tumour suppressor function of protein tyrosine phosphatase receptor-T.PMID 21517784Read ↗

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Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.Semantic proximity Read ↗

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Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.Semantic proximity Read ↗

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell functionSemantic proximity Read ↗

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