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Article

PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.

Scientific reports - 18 Jun 2018

Davis Thomas B, Yang Mingli, Schell Michael J, Wang Heiman, Ma Le, Pledger W Jack, Yeatman Timothy J

Abstract excerpt

Colorectal cancer (CRC) growth and progression is frequently driven by RAS pathway activation through upstream growth factor receptor activation or through mutational activation of KRAS or BRAF. Here we describe an additional mechanism by which the RAS pathway may be modulated in CRC. PTPRS, a receptor-type protein tyrosine phosphatase, appears to regulate RAS pathway activation through ERK. PTPRS modulates ERK...

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Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase Kinases

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Share to Proto-Oncogene Proteins c-akt

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Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

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Source

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Identifiers

PMID: 29915291
DOI: 10.1038/s41598-018-27584-x
PMCID: PMC6006154

Genes

PTPRS
BRAF
KRAS

Provenance

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