Article

The PTPRT pseudo-phosphatase domain is a denitrase

2017-12-22

Abstract excerpt

Protein tyrosine nitration occurs under both physiological and pathological conditions 1 . However, enzymes that remove this protein modification have not yet been identified. Here we report that the pseudo-phosphatase domain of protein tyrosine receptor T (PTPRT) is a denitrase that removes nitro-groups from tyrosine residues in paxillin. PTPRT normally functions as a tumor suppressor and is frequently mutated i...

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Literature Corpus work: e7259bb6-e7a8-53a2-8a44-10a8cee766b6
DOI: 10.1101/238980

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