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Article

Genetic alterations of protein tyrosine phosphatases in human cancers.

Oncogene - 23 Jul 2015

Zhao S, Sedwick D, Wang Z

Abstract excerpt

Protein tyrosine phosphatases (PTPs) are enzymes that remove phosphate from tyrosine residues in proteins. Recent whole-exome sequencing of human cancer genomes reveals that many PTPs are frequently mutated in a variety of cancers. Among these mutated PTPs, PTP receptor T (PTPRT) appears to be the most frequently mutated PTP in human cancers. Beside PTPN11, which functions as an oncogene in leukemia, genetic and...

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Topics

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Share to PTPN11 gene
Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phosphorylation

Share to Protein Processing, Post-Translational

Share to Protein Tyrosine Phosphatases

Source

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Identifiers

PMID: 25263441
DOI: 10.1038/onc.2014.326
PMCID: PMC4377308

Genes

PTPN11
PTPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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