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Article

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Zhang Xiaodong, Guo Ailan, Yu Jianshi, Possemato Anthony, Chen Yueting, Zheng Weiping, Polakiewicz Roberto D, Kinzler Kenneth W, Vogelstein Bert, Velculescu Victor E, Wang Zhenghe John

Abstract excerpt

Protein tyrosine phosphatase (PTP) receptor T (PTPRT) is the most frequently mutated PTP in human cancers. However, the cell signaling pathways regulated by PTPRT have not yet been elucidated. Here, we report identification of signal transducer and activator of transcription 3 (STAT3) as a substr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 17360477
DOI: 10.1073/pnas.0611665104
PMCID: PMC1802729

Genes

STAT3
PTPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17360477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.PMID 17360477Read ↗

Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling.Semantic proximity Read ↗

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Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer.Semantic proximity Read ↗

Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancerSemantic proximity Read ↗

Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.Semantic proximity Read ↗

Negative regulators of STAT3 signaling pathway in cancersSemantic proximity Read ↗

Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer TherapySemantic proximity Read ↗

Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types.Semantic proximity Read ↗

Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.Semantic proximity Read ↗

PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.Semantic proximity Read ↗

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