Article
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010
Zhao Yiqing, Zhang Xiaodong, Guda Kishore, Lawrence Earl, Sun Qun, Watanabe Toshio, Iwakura Yoichiro, Asano Masahide, Wei Lanlan, Yang Zhirong, Zheng Weiping, Dawson Dawn, Willis Joseph, Markowitz Sanford D, Satake Masanobu, Wang Zhenghe
Abstract excerpt
Protein tyrosine phosphatase receptor-type T (PTPRT) is the most frequently mutated tyrosine phosphatase in human cancers. However, the cell signaling pathways regulated by PTPRT largely remain to be elucidated. Here, we show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88 (Y88) in colorectal cancer (CRC) cells. We engineered CRC...
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