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Article

Further activation of FLT3 mutants by FLT3 ligand.

Oncogene - 22 Sept 2011

Zheng R, Bailey E, Nguyen B, Yang X, Piloto O, Levis M, Small D

Abstract excerpt

Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL)-independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficient (FL(-/-)) murine embryo fibroblast (MEF) cell line was established. Expression of FLT3/ITD and FLT3/TKD...

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Share to Cell Line, Tumor
Share to fms-Like Tyrosine Kinase 3
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

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Source

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Identifiers

PMID: 21516120
DOI: 10.1038/onc.2011.110
PMCID: PMC3155740

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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