Article
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells.
Blood - 1 Jan 2004
Zheng Rui, Levis Mark, Piloto Obdulio, Brown Patrick, Baldwin Brenda R, Gorin Norbert C, Beran Miloslav, Zhu Zhenping, Ludwig Dale, Hicklin Dan, Witte Larry, Li Yiwen, Small Donald
Abstract excerpt
The FLT3 receptor tyrosine kinase is highly expressed in most acute leukemias and frequently mutated in acute myeloid leukemia (AML). The mutated form of the receptor is constitutively activated and known to play an important role in AML, but the activation state of the overexpressed wild-type (wt) receptor is, at present, unknown. In this study, we examined the activation state of the wild-type receptor in AML....
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