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Article

The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis.

International journal of molecular sciences - 24 May 2017

Tsapogas Panagiotis, Mooney Ciaran James, Brown Geoffrey, Rolink Antonius

Abstract excerpt

The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Activating mutations of Flt3 are frequently found in acute myeloid leukemia (AML) patients and associated with a poor clinical...

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Share to Drug Discovery
Share to fms-Like Tyrosine Kinase 3
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid

Share to Membrane Proteins

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Source

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Identifiers

PMID: 28538663
DOI: 10.3390/ijms18061115
PMCID: PMC5485939

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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