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Article

Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.

Blood - 15 Oct 2003

Minami Yosuke, Yamamoto Kazuhito, Kiyoi Hitoshi, Ueda Ryuzo, Saito Hidehiko, Naoe Tomoki

Abstract excerpt

An internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 (FLT3/ITD) has been found in 20% of patients with acute myeloid leukemia (AML) and is correlated with leukocytosis and a poor prognosis. Here, we compared the antiapoptotic effects of wild-type FLT3 (WtFLT3) and FLT3/ITD in terms of the regulation of Bcl-2 family members. In a murine myeloid cell line, 32D, interleukin-3 (IL-3)...

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Source

Identifiers

PMID: 12842996
DOI: 10.1182/blood-2002-12-3813

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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