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Article

Effects of FLT3 Ligand on Proliferation and Survival of Myeloid Leukemia Cells

1 Jan 1999

Abstract excerpt

FLT3 ligand (FL) acting through its tyrosine kinase receptor FLT3 has pleiotropic and potent effects on hematopoietic cells. The well-described involvement of this ligand-receptor pair in physiological hematopoiesis raised the question whether FL and FLT3 also play a role in the pathobiology of leukemia. Following the early discovery of high receptor expression by myeloid leukemia cells, several investigators...

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PMID: 10194124
DOI: 10.3109/10428199909093728

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