Article

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways

2000-12-01

Abstract excerpt

Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications (ITD) occur in 20% of patients with acute myeloid leukemia. They are associated with a poor prognosis of the disease. In this study, we characterized the oncogenic potential and signaling properties of Flt3 mutations. We constructed chimeric molecules that consisted of the murine Flt3 backbone and a 510-base pair huma...

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Literature Corpus work: 91fb8666-16b4-507b-85ae-9f6bb6dad913
DOI: 10.1182/blood.v96.12.3907.h8003907_3907_3914

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