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Article

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.

Blood - 15 Feb 2005

Kim Kyu-Tae, Baird Kristin, Ahn Joon-Young, Meltzer Paul, Lilly Michael, Levis Mark, Small Donald

Abstract excerpt

Constitutively activating internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) play an important role in leukemogenesis, and their presence is associated with poor prognosis in acute myeloid leukemia (AML). To better understand FLT3 signaling in leukemogenesis, we have examined the changes in gene expression induced by FLT3/ITD or constitutively activated...

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Source

Identifiers

PMID: 15498859
DOI: 10.1182/blood-2004-05-2006

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival.PMID 15498859Read ↗

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