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Article

CD8+ T-Cell Exhaustion Phenotype in Chronic Hepatitis C Virus Infection Is Associated With Epitope Sequence Variation.

Frontiers in immunology - 1 Jan 2022

Osuch Sylwia, Laskus Tomasz, Perlejewski Karol, Berak Hanna, Bukowska-Ośko Iwona, Pollak Agnieszka, Zielenkiewicz Magdalena, Radkowski Marek, Caraballo Cortés Kamila

Abstract excerpt

Background and Aims: During chronic hepatitis C virus (HCV) infection, CD8+ T-cells become functionally exhausted, undergoing progressive phenotypic changes, i.e., overexpression of "inhibitory" molecules such as PD-1 (programmed cell death protein 1) and/or Tim-3 (T-cell immunoglobulin and mucin domain-containing molecule-3). The extreme intrahost genetic diversity of HCV is a major mechanism of immune system...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35386708
DOI: 10.3389/fimmu.2022.832206
PMCID: PMC8977521

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