Article
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
The Journal of allergy and clinical immunology - 1 Jan 2006
Li Huiling, Romieu Isabelle, Sienra-Monge Juan-Jose, Ramirez-Aguilar Matiana, Estela Del Rio-Navarro Blanca, Kistner Emily O, Gjessing Håkon K, Lara-Sanchez Irma Del Carmen, Chiu Grace Y, London Stephanie J
Abstract excerpt
BACKGROUND: A recent microarray study implicated arginase I (ARG1) and arginase II (ARG2) in mouse allergic asthma models and human asthma. OBJECTIVES: To examine the association between genetic variation in ARG1 and ARG2 and childhood asthma and atopy risk. METHODS: We enrolled 433 case-parent triads, consisting of patients with asthma 4 to 17 years old and their biologic parents, from the allergy clinic of a...
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