Article
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
The Journal of allergy and clinical immunology - 1 Jul 2014
van der Valk Ralf Jp, Duijts Liesbeth, Timpson Nicolas J, Salam Muhammad T, Standl Marie, Curtin John A, Genuneit Jon, Kerhof Marjan, Kreiner-Møller Eskil, Cáceres Alejandro, Gref Anna, Liang Liming L, Taal H Rob, Bouzigon Emmanuelle, Demenais Florence, Nadif Rachel, Ober Carole, Thompson Emma E, Estrada Karol, Hofman Albert, Uitterlinden André G, van Duijn Cornélia, Rivadeneira Fernando, Li Xia, Eckel Sandrah P, Berhane Kiros, Gauderman W James, Granell Raquel, Evans David M, St Pourcain Beate, McArdle Wendy, Kemp John P, Smith George Davey, Tiesler Carla Mt, Flexeder Claudia, Simpson Angela, Murray Clare S, Fuchs Oliver, Postma Dirkje S, Bønnelykke Klaus, Torrent Maties, Andersson Martin, Sleiman Patrick, Hakonarson Hakon, Cookson William O, Moffatt Miriam F, Paternoster Lavinia, Melén Erik, Sunyer Jordi, Bisgaard Hans, Koppelman Gerard H, Ege Markus, Custovic Adnan, Heinrich Joachim, Gilliland Frank D, Henderson Alexander J, Jaddoe Vincent Wv, de Jongste Johan C
Abstract excerpt
BACKGROUND: The fraction of exhaled nitric oxide (Feno) value is a biomarker of eosinophilic airway inflammation and is associated with childhood asthma. Identification of common genetic variants associated with childhood Feno values might help to define biological mechanisms related to specific asthma phenotypes. OBJECTIVE: We sought to identify the genetic variants associated with childhood Feno values and...
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