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Article

Roles of arginase variants, atopy, and ozone in childhood asthma.

The Journal of allergy and clinical immunology - 1 Mar 2009

Salam Muhammad T, Islam Talat, Gauderman W James, Gilliland Frank D

Abstract excerpt

BACKGROUND: Arginases (encoded by ARG1 and ARG2 genes) might play an important role in asthma pathogenesis through effects on nitrosative stress. Arginase expression is upregulated in asthma and varies with T(H)2 cytokine levels and oxidative stress. OBJECTIVE: We aimed to examine whether variants in these genes are associated with asthma and whether atopy and exposures to smoking and air pollution influence the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19281908
DOI: 10.1016/j.jaci.2008.12.020
PMCID: PMC2913574

Genes

ARG1
ARG2

Provenance

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