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Article

An EGFR-ERK-SOX9 Signaling Cascade Links Urothelial Development and Regeneration to Cancer

22 Apr 2011

Abstract excerpt

Like many carcinomas, urothelial carcinoma (UroCa) is associated with chronic injury. A better understanding of this association could inform improved strategies for preventing and treating this disease. We investigated the expression, regulation, and function of the transcriptional regulator SRY-related high-mobility group box 9 (Sox9) in urothelial development, injury repair, and cancer. In mouse bladders, Sox9...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 21512138
DOI: 10.1158/0008-5472.can-10-3072

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