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Article

SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys

22 Feb 2024

Abstract excerpt

The steps governing healing with or without fibrosis within the same microenvironment are unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate SOX9 for self-restoration. Using a multimodal approach for a head-to-head comparison of injury-induced SOX9 lineages, we identified a dynamic SOX9 switch in repairing epithelia. Lineages that regenerated epithelia silenced SOX9 and...

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PMID: 38386758
DOI: 10.1126/science.add6371

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