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Article

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 2013

Pignon Jean-Christophe, Grisanzio Chiara, Geng Yan, Song Jiaxi, Shivdasani Ramesh A, Signoretti Sabina

Abstract excerpt

The tumor protein p63 (p63), and more specifically the NH2-terminal truncated (ΔN) p63 isoform, is a marker of basal epithelial cells and is required for normal development of several epithelial tissues, including the bladder and prostate glands. Although p63-expressing cells are proposed to be the stem cells of the developing prostate epithelium and bladder urothelium, cell lineages in these endoderm-derived...

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Identifiers

PMID: 23620512
DOI: 10.1073/pnas.1221216110
PMCID: PMC3657776

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