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Article

SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer

1 Aug 2017

Abstract excerpt

It has been reported that functionally distinct cancer stem cells (CSCs) exist in human bladder cancer (BCa). Here, we found that Sox2, a transcription factor that is well characterized as a marker for stem cells, is upregulated in both mouse and human BCa. Sox2 expression is absent in normal urothelial cells, but it begins to be expressed in pre-neoplastic bladder tumors and continues to be expressed in invasive...

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Identifiers

PMID: 28793245
DOI: 10.1016/j.stemcr.2017.07.004

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