Article
Genetic polymorphisms of RAGE and risk of ulcerative colitis in a Chinese population.
Immunology letters - 1 Feb 2016
Wang Jiafeng, Zeng Juncheng, Wang Hao, Ye Shicai, Bi Yuntian, Zhou Yulan, Li Keshen, Zhou Yu
Abstract excerpt
The receptor for advanced glycation end products (RAGE) and its proinflammatory ligands are critically implicated in the pathological progression of ulcerative colitis (UC). Functional polymorphisms in the regulatory elements and/or ligand-binding regions of the RAGE gene affect the expression and function of RAGE and thus may increase susceptibility to UC. In this study, a total of 266 unrelated UC patients and...
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