Article
Post-translational modifications, a key process in CD36 function: lessons from the spontaneously hypertensive rat heart.
Journal of molecular and cellular cardiology - 1 Jul 2011
Lauzier Benjamin, Merlen Clémence, Vaillant Fanny, McDuff Janie, Bouchard Bertrand, Beguin Pauline C, Dolinsky Vernon W, Foisy Sylvain, Villeneuve Louis R, Labarthe François, Dyck Jason R B, Allen Bruce G, Charron Guy, Des Rosiers Christine
Abstract excerpt
CD36, a multifunctional protein, is involved in cardiac long chain fatty acid (LCFA) metabolism and in the etiology of heart diseases, yet the functional impact of Cd36 gene variants remains unclear. In 7-week-old spontaneously hypertensive rats (SHR), which, like humans, carry numerous mutations in Cd36, we tested the hypothesis that their restricted cardiac LCFA utilization occurs prior to hypertrophy due to...
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