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Article

Does reversible cysteine oxidation link the Western diet to cardiac dysfunction?

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2014

Behring Jessica B, Kumar Vikas, Whelan Stephen A, Chauhan Pratibha, Siwik Deborah A, Costello Catherine E, Colucci Wilson S, Cohen Richard A, McComb Mark E, Bachschmid Markus M

Abstract excerpt

Using a novel cysteine thiol labeling strategy coupled with mass spectrometric analysis, we identified and quantified the changes in global reversible cysteine oxidation of proteins in the left ventricle of hearts from mice with metabolic syndrome-associated diastolic dysfunction. This phenotype was induced by feeding a high-fat, high-sucrose, type-2 diabetogenic diet to C57BL/6J mice for 8 mo. The extent of...

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Identifiers

PMID: 24469991
DOI: 10.1096/fj.13-233445
PMCID: PMC4046179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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