Article
A simple allele-specific polymerase chain reaction method to detect the Gly143Glu polymorphism in the human carboxylesterase 1 gene: importance of genotyping for pharmacogenetic treatment.
Genetic testing and molecular biomarkers - 1 Dec 2010
Walter Soria Néstor, Belaus Andrea, Galván Cristian, Ana Pasquali María, Velez Pablo, Del Carmen Montes Cecilia, Beltramo Dante M
Abstract excerpt
Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the hydrolysis of many exogenous compounds. Alterations in CES sequences could lead to variability in both the inactivation of drugs and the activation of prodrugs. The human CES1 gene encodes for the enzyme carboxylesterase 1, a serine est...
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