Article
Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology.
Breast cancer research and treatment - 1 Feb 2012
Geyer Felipe C, de Biase Dario, Lambros Maryou B K, Ragazzi Moira, Lopez-Garcia Maria A, Natrajan Rachael, Mackay Alan, Kurelac Ivana, Gasparre Giuseppe, Ashworth Alan, Eusebi Vincenzo, Reis-Filho Jorge S, Tallini Giovanni
Abstract excerpt
Oncocytic carcinomas are composed of mitochondrion-rich cells. Though recognised by the WHO classification as a histological special type of breast cancer, their status as a discrete pathological entity remains a matter of contention. Given that oncocytic tumours of other anatomical sites display distinct clinico-pathological and molecular features, we sought to define the molecular genetic features of...
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