Article
The genetic landscape of breast carcinomas with neuroendocrine differentiation.
The Journal of pathology - 1 Feb 2017
Marchiò Caterina, Geyer Felipe C, Ng Charlotte Ky, Piscuoglio Salvatore, De Filippo Maria R, Cupo Marco, Schultheis Anne M, Lim Raymond S, Burke Kathleen A, Guerini-Rocco Elena, Papotti Mauro, Norton Larry, Sapino Anna, Weigelt Britta, Reis-Filho Jorge S
Abstract excerpt
Neuroendocrine breast carcinomas (NBCs) account for 2-5% of all invasive breast cancers, and are histologically similar to neuroendocrine tumours from other sites. They typically express oestrogen receptor (ER), and are HER2-negative and of luminal 'intrinsic' subtype. Here, we sought to define the mutational profile of NBCs, and to investigate whether NBCs and common forms of luminal (ER+ /HER2- ) breast...
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