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Article

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.

Organic & biomolecular chemistry - 7 Apr 2011

Kwan David H, Tosin Manuela, Schläger Nadin, Schulz Frank, Leadlay Peter F

Abstract excerpt

Ketoreductase enzymes are responsible for the generation of hydroxyl stereocentres during the biosynthesis of complex polyketide natural products. Previous studies of isolated polyketide ketoreductases have shown that the stereospecificity of ketoreduction can be switched by mutagenesis of selected active site amino acids. We show here that in the context of the intact polyketide synthase multienzyme the same...

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Identifiers

PMID: 21340070
DOI: 10.1039/c1ob00022e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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