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Article

Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.

Journal of cellular physiology - 1 Jul 2011

Yin Hao, Jiang Yulan, Li Haijie, Li Jingjing, Gui Yu, Zheng Xi-Long

Abstract excerpt

Myocardin is a transcriptional co-activator of serum response factor (SRF) and can be degraded through ubiquitin-proteasome system. Our preliminary studies unexpectedly revealed that accumulation of myocardin in response to proteasome inhibition by MG132 or lactacystin resulted in decrease of transcriptional activity of myocardin as indicated by reduced expression of SMC contractile marker genes (SM α-actin,...

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Source

Identifiers

PMID: 21506120
DOI: 10.1002/jcp.22519

Genes

SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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