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Article

Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degeneration.

Aging - 4 Nov 2020

Zhang Wenjing, Cheng Wen, Parlato Rosanna, Guo Xiaosun, Cui Xiaopei, Dai Chaochao, Xu Lei, Zhu Jiankang, Zhu Min, Luo Kun, Zhang Wencheng, Dong Bo, Wang Jianli, Jiang Fan

Abstract excerpt

Senescence of smooth muscle cells (SMCs) has a crucial role in the pathogenesis of abdominal aortic aneurysm (AAA), a disease of vascular degeneration. Perturbation of cellular ribosomal DNA (rDNA) transcription triggers nucleolar stress response. Previously we demonstrated that induction of nucleolar stress in SMCs elicited cell cycle arrest via the ataxia-telangiectasia mutated (ATM)/ATM- and Rad3-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33146634
DOI: 10.18632/aging.104094
PMCID: PMC7695416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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