Article
Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance.
Antimicrobial agents and chemotherapy - 1 Aug 2014
Pham Cau D, Iqbal Naureen, Bolden Carol B, Kuykendall Randall J, Harrison Lee H, Farley Monica M, Schaffner William, Beldavs Zintars G, Chiller Tom M, Park Benjamin J, Cleveland Angela A, Lockhart Shawn R
Abstract excerpt
Candida glabrata is the second leading cause of candidemia in U.S. hospitals. Current guidelines suggest that an echinocandin be used as the primary therapy for the treatment of C. glabrata disease due to the high rate of resistance to fluconazole. Recent case reports indicate that C. glabrata resistance to echinocandins may be increasing. We performed susceptibility testing on 1,380 isolates of C. glabrata...
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