Article
Resistance to echinocandin-class antifungal drugs.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jun 2007
Perlin David S
Abstract excerpt
Invasive fungal infections cause morbidity and mortality in severely ill patients, and limited drug classes restrict treatment choices. The echinocandin drugs are the first new class of antifungal compounds that target the fungal cell wall by blocking beta-1,3-d-glucan synthase. Elevated MIC values with occasional treatment failure have been reported for strains of Candida. Yet, an uncertain correlation exists...
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