Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abdominal candidiasis is a hidden reservoir of echinocandin resistance.

Antimicrobial agents and chemotherapy - 1 Dec 2014

Shields Ryan K, Nguyen M Hong, Press Ellen G, Clancy Cornelius J

Abstract excerpt

FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure (P = 0.01), breakthrough infections (P = 0.03), and therapeutic failures despite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candida albicans
Share to Candida glabrata

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Candidiasis

Share to Drug Resistance, Fungal

Share to Echinocandins

Share to Peritonitis

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 25288081
DOI: 10.1128/AAC.04134-14
PMCID: PMC4249510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abdominal candidiasis is a hidden reservoir of echinocandin resistance.PMID 25288081Read ↗

Clinical perspectives on echinocandin resistance among Candida species.Semantic proximity Read ↗

FKS mutant Candida glabrata: risk factors and outcomes in patients with candidemia.Semantic proximity Read ↗

Emergence of echinocandin-resistant Candida spp. in a hospital setting: a consequence of 10 years of increasing use of antifungal therapy?Semantic proximity Read ↗

Novel FKS mutations associated with echinocandin resistance in Candida species.Semantic proximity Read ↗

Echinocandin resistance: an emerging clinical problem?Semantic proximity Read ↗

Rapid emergence of echinocandin resistance during Candida kefyr fungemia treatment with caspofungin.Semantic proximity Read ↗

Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.Semantic proximity Read ↗

Echinocandin Resistance in Candida Species Isolates from Liver Transplant Recipients.Semantic proximity Read ↗

Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance.Semantic proximity Read ↗

Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.Semantic proximity Read ↗

Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance.Semantic proximity Read ↗

The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.