Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance.

Proceedings of the National Academy of Sciences of the United States of America - 3 May 2011

Sampah Maame Efua S, Shen Lin, Jilek Benjamin L, Siliciano Robert F

Abstract excerpt

HIV-1 drug resistance is a major clinical problem. Resistance is evaluated using in vitro assays measuring the fold change in IC(50) caused by resistance mutations. Antiretroviral drugs are used at concentrations above IC(50), however, and inhibition at clinical concentrations can only be predicted from IC(50) if the shape of the dose-response curve is also known. Curve shape is influenced by cooperative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Viral
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to HIV Fusion Inhibitors

Share to HIV Integrase Inhibitors

Share to HIV Protease Inhibitors

Share to Inhibitory Concentration 50

Share to Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 21502494
DOI: 10.1073/pnas.1018360108
PMCID: PMC3088572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance.PMID 21502494Read ↗

The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope.Semantic proximity Read ↗

Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistanceSemantic proximity Read ↗

A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs.Semantic proximity Read ↗

HIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selection.Semantic proximity Read ↗

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.Semantic proximity Read ↗

Quantitative evaluation of the antiretroviral efficacy of dolutegravir.Semantic proximity Read ↗

HIV drug resistance: Insights from mathematical modellingSemantic proximity Read ↗

Temporal Evolution of Drug Resistance to HIV Integrase Inhibitors.Semantic proximity Read ↗

Determination of Phenotypic Resistance Cutoffs From Routine Clinical Data.Semantic proximity Read ↗

Modeling the HIV Protease Inhibitor Adherence–Resistance Curve by Use of Empirically Derived EstimatesSemantic proximity Read ↗

Retracing the Evolutionary Pathways of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors: Virus Fitness in the Absence and in the Presence of DrugSemantic proximity Read ↗

Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.