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Article

Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance

26 Aug 2013

Abstract excerpt

HIV-1 protease inhibitors (PIs) are among the most effective antiretroviral drugs. They are characterized by highly cooperative dose-response curves that are not explained by current pharmacodynamic theory. An unresolved problem affecting the clinical use of PIs is that patients who fail PI-containing regimens often have virus that lacks protease mutations, in apparent violation of fundamental evolutionary...

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PMID: 23979165
DOI: 10.1172/jci67399

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