Article
A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs.
Science translational medicine - 13 Jul 2011
Shen Lin, Rabi S Alireza, Sedaghat Ahmad R, Shan Liang, Lai Jun, Xing Sifei, Siliciano Robert F
Abstract excerpt
Control of HIV-1 replication was first achieved with regimens that included a nonnucleoside reverse transcriptase inhibitor (NNRTI) or a protease inhibitor (PI); however, an explanation for the high antiviral activity of these drugs has been lacking. Indeed, conventional pharmacodynamic measures like IC(50) (drug concentration causing 50% inhibition) do not differentiate NNRTIs and PIs from less active nucleoside...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.