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Article

Determination of Phenotypic Resistance Cutoffs From Routine Clinical Data.

Journal of acquired immune deficiency syndromes (1999) - 15 Apr 2017

Pironti Alejandro, Walter Hauke, Pfeifer Nico, Knops Elena, Lübke Nadine, Büch Joachim, Di Giambenedetto Simona, Kaiser Rolf, Lengauer Thomas

Abstract excerpt

BACKGROUND: HIV-1 drug resistance can be measured with phenotypic drug-resistance tests. However, the output of these tests, the resistance factor (RF), requires interpretation with respect to the in vivo activity of the tested variant. Specifically, the dynamic range of the RF for each drug has to be divided into a suitable number of clinically meaningful intervals. METHODS: We calculated a...

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Identifiers

PMID: 27787339
DOI: 10.1097/QAI.0000000000001198
PMCID: PMC5351752

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