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Article

Quantitative evaluation of the antiretroviral efficacy of dolutegravir.

JCI insight - 17 Nov 2016

Laskey Sarah B, Siliciano Robert F

Abstract excerpt

The second-generation HIV-1 integrase strand transfer inhibitor (InSTI) dolutegravir (DTG) has had a major impact on the treatment of HIV-1 infection. Here we describe important but previously undetermined pharmacodynamic parameters for DTG. We show that the dose-response curve slope, which indicates cooperativity and is a major determinant of antiviral activity, is higher for DTG than for first-generation...

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Identifiers

PMID: 27882352
DOI: 10.1172/jci.insight.90033
PMCID: PMC5111505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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