Article
The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope.
PloS one - 1 Jan 2016
Chang Shuai, Zhuang Daomin, Guo Wei, Li Lin, Zhang Wenfu, Liu Siyang, Li Hanping, Liu Yongjian, Bao Zuoyi, Han Jingwan, Song Hongbin, Li Jingyun
Abstract excerpt
OBJECTIVES: This study was designed to identify common HIV-1 mutation complexes affecting the slope of inhibition curve, and to propose a new parameter incorporating both the IC50 and the slope to evaluate phenotypic resistance. METHODS: Utilizing site-directed mutagenesis, we constructed 22 HIV-1 common mutation complexes. IC50 and slope of 10 representative approved drugs and a novel agent against these...
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