Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus.

Cancer research - 1 Jul 2011

Pierce Brandon L, Ahsan Habibul

Abstract excerpt

In genome-wide association (GWA) studies, hundreds of thousands of single-nucleotide polymorphisms (SNP) are tested for association with a disease trait. Typically, GWA studies give equal consideration to all SNPs tested, regardless of existing knowledge of an SNP's functionality or biological plausibility of association. Because many tests are conducted, very low statistical significance thresholds (P < 5 ×...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Genome-Wide Association Study

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Pancreatic Neoplasms

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 21498636
DOI: 10.1158/0008-5472.CAN-11-0124
PMCID: PMC3129443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus.PMID 21498636Read ↗

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.Semantic proximity Read ↗

Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals.Semantic proximity Read ↗

Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.Semantic proximity Read ↗

Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of multiple cardiovascular disease risk factorsSemantic proximity Read ↗

Unidentified genetic variants influence pancreatic cancer risk: an analysis of polygenic susceptibility in the PanScan study.Semantic proximity Read ↗

An ancestry-enriched HNF4A variant and GP2 reveal distinct mechanisms of type 2 diabetes in exome-wide study of 13,674 cases and 41,024 controlsSemantic proximity Read ↗

Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 StudySemantic proximity Read ↗

A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.Semantic proximity Read ↗

Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.Semantic proximity Read ↗

Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteinsSemantic proximity Read ↗

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.