Article
Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Sept 2024
Ni Zhanmo, Kundu Prosenjit, McKean David F, Wheeler William, Albanes Demetrius, Andreotti Gabriella, Antwi Samuel O, Arslan Alan A, Bamlet William R, Beane-Freeman Laura E, Berndt Sonja I, Bracci Paige M, Brennan Paul, Buring Julie E, Chanock Stephen J, Gallinger Steven, Gaziano J M, Giles Graham G, Giovannucci Edward L, Goggins Michael G, Goodman Phyllis J, Haiman Christopher A, Hassan Manal M, Holly Elizabeth A, Hung Rayjean J, Katzke Verena, Kooperberg Charles, Kraft Peter, LeMarchand Loic, Li Donghui, McCullough Marjorie L, Milne Roger L, Moore Steven C, Neale Rachel E, Oberg Ann L, Patel Alpa V, Peters Ulrike, Rabe Kari G, Risch Harvey A, Shu Xiao-Ou, Smith-Byrne Karl, Visvanathan Kala, Wactawski-Wende Jean, White Emily, Wolpin Brian M, Yu Herbert, Zeleniuch-Jacquotte Anne, Zheng Wei, Zhong Jun, Amundadottir Laufey T, Stolzenberg-Solomon Rachael Z, Klein Alison P
Abstract excerpt
BACKGROUND: Pancreatic cancer is a leading cause of cancer-related death globally. Risk factors for pancreatic cancer include common genetic variants and potentially heavy alcohol consumption. We assessed if genetic variants modify the association between heavy alcohol consumption and pancreatic cancer risk. METHODS: We conducted a genome-wide interaction analysis of single-nucleotide polymorphisms (SNP) by heavy...
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