Article
Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.
PloS one - 28 May 2010
Elliott Katherine S, Zeggini Eleftheria, McCarthy Mark I, Gudmundsson Julius, Sulem Patrick, Stacey Simon N, Thorlacius Steinunn, Amundadottir Laufey, Grönberg Henrik, Xu Jianfeng, Gaborieau Valerie, Eeles Rosalind A, Neal David E, Donovan Jenny L, Hamdy Freddie C, Muir Kenneth, Hwang Shih-Jen, Spitz Margaret R, Zanke Brent, Carvajal-Carmona Luis, Brown Kevin M, Hayward Nicholas K, Macgregor Stuart, Tomlinson Ian P M, Lemire Mathieu, Amos Christopher I, Murabito Joanne M, Isaacs William B, Easton Douglas F, Brennan Paul, Barkardottir Rosa B, Gudbjartsson Daniel F, Rafnar Thorunn, Hunter David J, Chanock Stephen J, Stefansson Kari, Ioannidis John P A
Abstract excerpt
BACKGROUND: Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may have an effect on cancer risk in general versus a specific effect on prostate...
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