Article

An ancestry-enriched HNF4A variant and GP2 reveal distinct mechanisms of type 2 diabetes in exome-wide study of 13,674 cases and 41,024 controls

2025-09-26

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<h4>Abstract / Introductory Paragraph</h4> Type 2 diabetes (T2D) is a common and complex metabolic condition with significant heterogeneity within and across ancestries 1–4 . Compared with individuals of European ancestry (EUR), people of south Asian ancestry (SAS) have two to four-fold higher risk of T2D, develop the disease at younger ages and lower body mass index (BMI), and experience more rapid progression...

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Literature Corpus work: 89cc3be6-5679-5379-915b-c5425e1a5cad
DOI: 10.1101/2025.09.24.25336527

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