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Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study

23 Apr 2019

Abstract excerpt

BACKGROUND: Pancreatic cancer is the fourth-leading cause of cancer death in both men and women in the United States. The currently identified common susceptibility loci account for a small fraction of estimated heritability. We sought to estimate overall heritability of pancreatic cancer and partition the heritability by variant frequencies and functional annotations. METHODS: Analysis using the genome-based...

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PMID: 31015203
DOI: 10.1158/1055-9965.epi-18-1235

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